Novel analysis methods used for Huntington’s disease

Novel analysis methods used for Huntingtons disease
Spread the love


Neural networks of the human brain; a 3D illustration. Credit: Lancaster University

Advertisements

The genetic disease Huntington’s not only affects nerve cells in the brain but also has widespread effects on microscopic blood vessels according to research.

These changes to the vasculature were also observed in the pre-symptomatic stages of the disease, demonstrating the potential for this research for predicting brain health and evaluating the beneficial effects of lifestyle changes or treatments.

Huntington’s disease is an inherited genetic condition leading to dementia, with a progressive decline in a person’s movement, memory, and cognition. There is currently no cure.

Advertisements
Advertisements
Advertisements

In their study, published in Brain Communications, a research team investigated changes in the coordination between neuronal activity and the brain’s oxygenation in Huntington’s disease.

Advertisements

The vasculature and brain work together to ensure that the brain receives sufficient energy. In fact, the brain needs as much as 20% of the body’s energy consumption despite only weighing approximately 2% of the body’s weight.

The “neurovascular unit” consists of vasculature connected via brain cells called astrocytes to neurons and ensures that this cooperation is successful.

To assess the function of these neurovascular units, the researchers combined non-invasive measurement techniques and novel analysis methods developed by Lancaster’s Nonlinear and Biomedical Physics group.

Advertisements

Probes emitting infrared light were placed on the heads of participants in the study. The infrared light penetrated the skull harmlessly and enabled researchers to measure the brain’s blood oxygenation.

Electrodes, which can measure electrical activity from neurons, were also placed on the heads of participants. The researchers then studied the many rhythms related to the functioning of the brain and the cardiovascular system using mathematical techniques. These rhythms included the heart and respiration rates, related to the transport of nutrients and oxygen, as well as slower rhythms associated with local control of blood flow. Brain activity manifests in faster rhythms.

Efficient functioning of the brain depends on how well all these rhythms are orchestrated. To assess the efficiency of the neurovascular unit, both the strength and the coordination of these rhythms were assessed by computing their “power” and “phase coherence”.

Professor Aneta Stefanovska of Lancaster University said, “We are hopeful that the method described could be used to monitor the disease progression and to evaluate the effect of potential treatments or lifestyle changes in Huntington’s disease and other neurodegenerative diseases. We also hope that our study will stimulate new treatments of Huntington’s disease targeting the vasculature and brain metabolism.”

In addition to Stefanovska, the research team includes Juliane Bjerkan, Gemma Lancaster, and Peter McClintock from Lancaster University, Jan Kobal, Sanja Šešok and Bernard Meglič from the University Medical Centre in Ljubljana, Karol Budohoski from the Cambridge University Hospitals NHS Trust, and Peter Kirkpatrick from Cambridge University.

More information:
Juliane Bjerkan et al, The phase coherence of the neurovascular unit is reduced in Huntington’s disease, Brain Communications (2024). DOI: 10.1093/braincomms/fcae166

Citation:
Novel analysis methods used for Huntington’s disease (2024, June 9)
retrieved 9 June 2024
from https://medicalxpress.com/news/2024-06-analysis-methods-huntington-disease.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

Advertisements

Please Login to Comment.

Verified by MonsterInsights