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  • Funding: The research reported from the work of ELS and the present work were supported by Canadian Institutes of Health Research (CIHR) grants 37917, First Pilot Foundation Grant 143348 and Project Grant PJT 186248, a Canada Research Chair (CRC) on Hypertension and Vascular Research by the CRC Government of Canada/CIHR Program, by the Canada Fund for Innovation, and a Distinguished James McGill Professorship.

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  • Competing interests: We have read and understood the BMJ policy on declaration of interests and declare the following interests: ELS has been a member of advisory boards of Janssen Pharmaceuticals USA and Boehringer Ingelheim International; NDLF was a consultant for and received research grants from Recor Medical and was a consultant for Medtronic and Astra Zeneca.

  • Patient involvement: No patients were asked for input in the creation of this article.

  • Provenance and peer review: Commissioned; externally peer reviewed.



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